Largo Back Pain Related to Inflammation Reduced with Melatonin
Inflammation. Disc Degeneration. There is a relationship. Inflammation is the body’s response to harmful stimuli (injury, pathogens, metabolic stress – a disc herniation pushing on a nerve!) as it tries to repair itself before the harm was done. Hollstrom & Associates Inc is never shocked at what the body can do! Hollstrom & Associates Inc sees its Largo chiropractic care as a partner of the body’s system in healing particularly when spine pain is an issue. Chiropractic care utilizes many tools like spinal manipulation, exercise, and nutrition to help the body. Melatonin is one nutritional tool that is showing value by interrupting the inflammatory process related disc herniation that results in back pain, neck pain and other spine related pain.
DISC DEGENERATION AND INFLAMMATION AND 'AUTOPHAGY'
Inflammatory markers interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are associated with intervertebral disc degeneration. (1) IL-1 β in fact promotes itself, its own expression, by upregulating NLRP3 inflammasome activation. (2) The body regulates itself down to the cellular level via autophagy, the natural process via which the body’s cells clean out damaged (ie, by inflammation) or unneeded parts. In a recent study, melatonin boosted autophagy and lessened the degradation of the disc’s extracellular matrix (technically marked by a decrease in marker LC3B, autophagasomes and autolysosomes and inhibition of the NF-kB signaling pathway). The final conclusion was that melatonin inhibits intervertebral disc degeneration by promoting autophagy. (3) Wow. Hollstrom & Associates Inc is encouraged by this research to see just how well melatonin can work for Largo back pain linked to disc degeneration.
MELATONIN AND ITS HEALING WAYS FOR THE DISC
Disc degeneration is a very common malady seen at Hollstrom & Associates Inc that positive news of melatonin’s benefits are quite exciting. A new study explained how melatonin could modulate the extracellular matrix of the disc remodeling process initiated by IL-1 β. Further, melatonin reduced the inflammatory cell collection and reduced the release of associated inflammatory markers IL-1β, IL-6, and TNF-α. With this new finding that melatonin interrupted the IL-1B feedback loop, researchers postulated that melatonin may provide the healing process of intervertebral discs after damage was already present. (1) Hollstrom & Associates Inc continues following the new research regarding the role inflammation plays in Largo disc degeneration and melatonin’s role in combatting it.
INFLAMMATION AND MELATONIN
The significance of melatonin in helping to slow or stop painful conditions due to inflammation is rising. The description of melatonin as a multitasking molecule affecting mood, immunity, and energy among other mechanisms is quite appropriate. It’s also anti-oxidant, anti-aging, and anti-inflammatory, specifically by blocking the activation of inflammasomes (4) Melatonin’s formal chemical name is as about as long as its list of tasks: N-acetyl-5-methoxytryptamine. The pineal gland produces melatonin naturally. Melatonin impacts the body’s aging, anti-inflammatory, anti-apoptosis (cell death), and autophagy (cell-cleanout) processes. (1) Melatonin’s specific effect on inflammation and disc degeneration is most attention-getting to Hollstrom & Associates Inc and our Largo back pain patients.
CONTACT Hollstrom & Associates Inc
Listen to this PODCAST with Dr. Hrefna Sylvia based in Iceland where back pain isn’t much different from any other country on The Back Doctors Podcast with Dr. Michael Johnson as she describes how The Cox® Technic System of Spinal Pain Management addresses disc degeneration for relief of chronic low back pain in her patient.
Schedule your Largo chiropractic appointment with Hollstrom & Associates Inc now. We can discuss how inflammation affects your back pain and how melatonin may help with the related disc degeneration.
